2022
Yueli Xu, Jiaxian Yan1, Ye Tao, Xiaojun Qian, Chi Zhang, Libei Yin, Pengying Gu, Yehai Liu,Yueyin Pan, Renhong Tang*, Wei Jiang*, Rongbin Zhou*. Pituitary hormone a-MSH promotes tumor-induced myelopoiesis and immunosuppression. Science. 2022 Sep 2. [Pubmed] [Article]
Hualong Lin, Mingyang Yang, Cong Li, Bolong Lin, Xianming Deng*,Hongbin He* and Rongbin Zhou*. An RRx-001 Analogue With Potent Anti-NLRP3 Inflammasome Activity but Without High-Energy Nitro Functional Groups. Frontiers in Pharmacology. 2022 Feb 17. [Pubmed] [Article]
Cong Li, Hualong Lin, Hongbin He, Ming Ma*, Wei Jiang* and Rongbin Zhou*. Inhibition of the NLRP3 Inflammasome Activation by Manoalide Ameliorates Experimental Autoimmune Encephalomyelitis Pathogenesis. Frontiers in Cell and Developmental Biology. 2022 Feb 16. [Pubmed] [Article]
2021
Xuesen Zheng, Lei Liu, Guangxun Meng, Shu Zhu, Rongbin Zhou*, Wei Jiang*. IL-18 maintains the homeostasis of mucosal immune system via inflammasome-independent but microbiota-dependent manner. Science Bulletin. 2021 Oct 30. [Pubmed] [Article]
Xicui Zheng, Yingting Hou, Hongbin He, Yun Chen, Rongbin Zhou, Xiaqiong Wang*, Tao Gong*, Wei Jiang*. Synthetic vitamin K analogs inhibit inflammation by targeting the NLRP3 inflammasome. Cellular & Molecular Immunology. 2021 Oct 18. [Pubmed][Article]
Yi Huang, Wen Xu, Rongbin Zhou*. NLRP3 inflammasome activation and cell death. Cellular & Molecular Immunology. 2021 Sep 18. [Pubmed][Article]
Ming Ma, Guoyang Li, Minghui Qi, Wei Jiang*, Rongbin Zhou*. Inhibition of the Inflammasome Activity of NLRP3 Attenuates HDM-Induced Allergic Asthma. Frontiers in Immunology. 2021 Aug 3. [Pubmed][Article]
Xiaqiong Wang, Juan Cai , Bolong Lin, Ming Ma, Ye Tao, Yubo Zhou, Li Bai, Wei Jiang*, Rongbin Zhou*. GPR34-mediated sensing of lysophosphatidylserine released by apoptotic neutrophils activates type 3 innate lymphoid cells to mediate tissue repair. Immunity. 2021 Jun 8. [Pubmed][Article]
Yun Chen, Hongbin He, Bolong Lin, Yun Chen, Xianming Deng, Wei Jiang* Rongbin Zhou*. RRx-001 ameliorates inflammatory diseases by acting as a
potent covalent NLRP3 inhibitor. Cellular & Molecular Immunology. 2021 May 10. [Pubmed] [Article]
2020
Xicui Zheng, Yingting Hou, Hongbin He, Yun Chen, Rongbin Zhou, Xiaqiong Wang, Tao Gong, Wei Jiang. Synthetic vitamin K analogs inhibit inflammation by targeting the NLRP3 inflammasome. Cellular & Molecular Immunology. 2020 Sep 11. [Pubmed][Article]
Ye Tao, Yanqing Yang, Rongbin Zhou, Tao Gong. Golgi apparatus: an emerging platform for innate immunity. Trends in cell biology. 2020 Jun 1. [Pubmed][Article]
Yi Huang, Huanyu Wang, Yize Hao, Hualong Lin, Menghao Dong, Jin Ye, Lei Song, Yunzhi Wang, Qingqing Li, Benjie Shan, Yizhou Jiang, Hongqi Li, Zhiming Shao, Guido Kroemer, Huafeng Zhang, Li Bai, Tengchuan Jin, Chao Wang, Yuting Ma, Yongping Cai, Chen Ding, Suling Liu, Yueyin Pan, Wei Jiang, Rongbin Zhou. Myeloid PTEN promotes chemotherapy-induced NLRP3-inflammasome activation and antitumour immunity. Nature cell biology. 2020 May 4. [Pubmed][Article]
Yun Chen, Hongbin He, Hua Jiang, Li Li, Zhiyu Hu, Huiying Huang, Qingyan Xu, Rongbin Zhou, Xianming Deng. Discovery and optimization of 4-oxo-2-thioxo-thiazolidinones as NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inhibitors. Bioorganic & medicinal chemistry letters. 2020 Apil 1. [Pubmed][Article]
Tao Gong, Lei Liu, Wei Jiang, Rongbin Zhou. DAMP-sensing receptors in sterile inflammation and inflammatory diseases.Nature Reviews Immunology. 2020 Feb . [Pubmed][Article]
Tao Gong, Rongbin Zhou. ApoC3: an ‘alarmin’triggering sterile inflammation. Nature immunology. 2020 Jan. [Pubmed][Article]
Hua Jiang, Tao Gong, Rongbin Zhou. The strategies of targeting the NLRP3 inflammasome to treat inflammatory diseases. Advances in immunology. 2020 Jan. [Pubmed][Article]
2019
Lei Liu, Tao Gong, Wanyin Tao, Bolong Lin, Cong Li, Xuesen Zheng, Shu Zhu, Wei Jiang, Rongbin Zhou. Commensal viruses maintain intestinal intraepithelial lymphocytes via noncanonical RIG-I signaling. Nature immunology. 2019 Dec. [Pubmed][Article]
2018
Tang T, Gong T*, Jiang W*, Zhou R*. GPCRs in NLRP3 Inflammasome Activation, Regulation, and Therapeutics. Trends Pharmacol Sci. 2018 Jul 24. [Pubmed][Article]
Gong T, Jiang W*, Zhou R*. Control of Inflammasome Activation by Phosphorylation. Trends Biochem Sci. 2018 Jul 23. [Pubmed][Article]
He H, Jiang H, Chen Y, Ye J, Wang A, Wang C, Liu Q, Liang G, Deng X*, Jiang W*, Zhou R*. Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity. Nat Commun. 2018 Jun 29. [Pubmed][Article]
Huang Y, Jiang H, Chen Y, Wang X, Yang Y, Tao J, Deng X, Liang G, Zhang H, Jiang W*, Zhou R*. Tranilast directly targets NLRP3 to treat inflammasome-driven diseases. EMBO Mol Med. 2018 Mar 12. [Pubmed][Article]
Gong T, Yang Y, Jin T, Jiang W*, Zhou R*. Orchestration of NLRP3 Inflammasome Activation by Ion Fluxes. Trends Immunol. 2018 Feb 13. [Pubmed][Article]
2017
Qin Y, Su Z, Wu Y, Wu C, Jin S, Xie W, Jiang W, Zhou R, Cui J. NLRP11 disrupts MAVS signalosome to inhibit type I interferon signaling and virus-induced apoptosis. EMBO Rep. 2017 Nov 2.[Pubmed][Article]
Jiang H, He H, Chen Y, Huang W, Cheng J, Ye J, Wang A, Tao J, Wang C, Liu Q, Jin T, Jiang W*, Deng X*, Zhou R*. Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders. J Exp Med. 2017 Oct 11.[Pubmed][Article]
Tang T, Lang X, Xu C, Wang X, Gong T, Yang Y, Cui J, Bai L, Wang J, Jiang W*, Zhou R*. CLICs-dependent chloride efflux is an essential and proximal upstream event for NLRP3 inflammasome activation. Nat Commun. 2017 Aug 4. [Pubmed][Article]
Gong T, Wang X, Yang Y, Yan Y, Yu C, Zhou R, Jiang W*. Plant Lectins Activate the NLRP3 Inflammasome To Promote Inflammatory Disorders. J Immunol. 2017 Mar 1 [Pubmed][Article]
H JIANG, YQ YAN, W JIANG, RB ZHOU*. NLRP3 inflammasome: activation, regulation, and role in diseases. SCIENTIA SINICA Vitae. 2017 Jan [Article]
2016
Lang X, Tang T, Jin T, Ding C*, Zhou R*, Jiang W*. TRIM65-catalized ubiquitination is essential for MDA5-mediated antiviral innate immunity. J Exp Med. 2016 Dec [Pubmed][Article]
H JIANG, RB ZHOU*. NLRP3 inflammasome: A novel target for T2DM treatment? Chinese Science Bulletin. 2016 Sep 28 [Article]
Hou X, Hao X, Zheng M, Xu C, Wang J, Zhou R, Tian Z. CD205-TLR9-IL-12 axis contributes to CpG-induced oversensitive liver injury in HBsAg transgenic mice by promoting the interaction of NKT cells with Kupffer cells. Cell Mol Immunol. 2016 Apr 4 [Pubmed][Article]
2015
Yan Y, Jiang W, Liu L, Wang X, Ding C, Tian Z*, Zhou R*. Dopamine controls systemic inflammation through inhibition of NLRP3 inflammasome. Cell. 2015 Jan 15;160(1-2):62-73 [Pubmed][Article]
2014
Wang X, Jiang W, Yan Y, Gong T, Han J, Tian Z*, Zhou R*. RNA viruses promote activation of the NLRP3 inflammasome through a RIP1-RIP3-DRP1 signaling pathway. Nat Immunol. 2014 Dec;15(12):1126-33 [Pubmed][Article]
2013
Jiang W, Wang X, Zeng B, Liu L, Tardivel A, Wei H, Han J, MacDonald HR, Tschopp J, Tian Z*, Zhou R*. Recognition of gut microbiota by NOD2 is essential for the homeostasis of intestinal intraepithelial lymphocytes. J Exp Med. 2013 Oct 21;210(11):2465-76 [Pubmed][Article]
Yan Y, Jiang W, Spinetti T, Tardivel A, Castillo R, Bourquin C, Guarda G, Tian Z*, Tschopp J, Zhou R*. Omega-3 fatty acids prevent inflammation and metabolic disorder through inhibition of NLRP3 inflammasome activation. Immunity. 2013 Jun 27;38(6):1154-63 [Pubmed][Article]
Zhang Z, Xu X, Ma J, Wu J, Wang Y, Zhou R, Han J. Gene deletion of Gabarap enhances Nlrp3 inflammasome-dependent inflammatory responses. J Immunol. 2013 Apr 1;190(7):3517-24. [Pubmed][Article]
2012
Menu P, Mayor A, Zhou R, Tardivel A, Ichijo H, Mori K, Tschopp J. ER stress activates the NLRP3 inflammasome via an UPR-independent pathway. Cell Death Dis. 2012 Jan 26;3:e261. [Pubmed][Article]
2011
Zhou R, Yazdi AS, Menu P, Tschopp J. A role for mitochondria in NLRP3 inflammasome activation. Nature. 2011 Jan 13;469(7329):221-5. [Pubmed][Article]
2010
Jiang W, Ferrero I, Laurenti E, Trumpp A, MacDonald HR. c-Myc controls the development of CD8αα TCRαβ intestinal intraepithelial lymphocytes from thymic precursors by regulating IL-15-dependent survival. Blood. 2010 Jun 3;115(22):4431-8. [Pubmed][Article]
Zhou R, Tardivel A, Thorens B, Choi I, Tschopp J. Thioredoxin-interacting protein links oxidative stress to inflammasome activation. Nat Immunol. 2010 Feb;11(2):136-40. [Pubmed][Article]
Schroder K, Zhou R, Tschopp J. The NLRP3 inflammasome: a sensor for metabolic danger? Science. 2010 Jan 15;327(5963):296-300 [Pubmed][Article]